An analysis of the quality of evidence found in medical clinical trials has reportedly discovered that a significant number lack sufficient evidence necessary for guiding sound medical choices. The study, which is published in the May issue of the Journal of the American Medical Association, analyzed approximately 41,000 clinical trials, specifically related to the areas of cardiovascular medicine, mental health, and cancer treatment. Researchers reportedly found that 96% had 1000 or less test subjects and over 60% has 100 or less. In addition, researchers reported that 66% of all the trials were held at a single location rather than multiple sites.
According to Dr. Robert Califf, vice chancellor for clinical research at Duke University Medical Center, the analysis raises questions surrounding the most reliable methods for compiling evidence and reportedly, the ability of the researchers to implement, decipher, and report clinical results in a manner which would warrant the recommendation of a potential treatment or the deviation from a currently acceptable method of management. Dr Califf and his associates reviewed trials from a database website supervised by the National Library of Medicine, who preserves previous, current and future clinical research studies.
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