Letters of administration

Can letters of administration be granted again to some other person even if the same have been granted earlier to one person by the orders of the court.

HK daughter of HS received letters of admn/probate of the will of HS. both HK and HS expired. HK died intestate, leaving behind husband and two daughters and two sons. Both sons expired. Wife of one of the son now seeks letters of admn in respect of the estate of HK.

Advise.